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Issue 15, 2018
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Transition-metal-free decarboxylative bromination of aromatic carboxylic acids

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Abstract

Methods for the conversion of aliphatic acids to alkyl halides have progressed significantly over the past century, however, the analogous decarboxylative bromination of aromatic acids has remained a longstanding challenge. The development of efficient methods for the synthesis of aryl bromides is of great importance as they are versatile reagents in synthesis and are present in many functional molecules. Herein we report a transition metal-free decarboxylative bromination of aromatic acids. The reaction is applicable to many electron-rich aromatic and heteroaromatic acids which have previously proved poor substrates for Hunsdiecker-type reactions. In addition, our preliminary mechanistic study suggests that radical intermediates are not involved in this reaction, which is in contrast to classical Hunsdiecker-type reactivity. Overall, the process demonstrates a useful method for producing valuable reagents from inexpensive and abundant starting materials.

Graphical abstract: Transition-metal-free decarboxylative bromination of aromatic carboxylic acids

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Supplementary files

Article information


Submitted
02 Mar 2018
Accepted
24 Mar 2018
First published
26 Mar 2018

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2018,9, 3860-3865
Article type
Edge Article

Transition-metal-free decarboxylative bromination of aromatic carboxylic acids

Jacob M. Quibell, G. J. P. Perry, D. M. Cannas and I. Larrosa, Chem. Sci., 2018, 9, 3860
DOI: 10.1039/C8SC01016A

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    [Original citation] - Published by The Royal Society of Chemistry.

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