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Issue 8, 2018
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Multicomponent mechanochemical synthesis

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Historically, the use of mechanochemical methods in synthesis has been almost negligible, but their perception by the synthetic community has changed in recent years and they are on their way to becoming mainstream. However, the hybridization of mechanochemical synthesis with methodologies designed to increase synthetic efficiency by allowing the generation of several bonds in a single operation has taken off only recently, but it already constitutes a very promising approach to sustainable chemistry. In this context, we provide in this Perspective a critical summary and discussion of the main known synthetic methods based on mechanochemical multicomponent reactions.

Graphical abstract: Multicomponent mechanochemical synthesis

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The article was received on 18 Dec 2017, accepted on 28 Jan 2018 and first published on 29 Jan 2018

Article type: Perspective
DOI: 10.1039/C7SC05370C
Citation: Chem. Sci., 2018,9, 2042-2064
  • Open access: Creative Commons BY license
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    Multicomponent mechanochemical synthesis

    M. Leonardi, M. Villacampa and J. C. Menéndez, Chem. Sci., 2018, 9, 2042
    DOI: 10.1039/C7SC05370C

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