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Issue 8, 2018
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Multicomponent mechanochemical synthesis

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Historically, the use of mechanochemical methods in synthesis has been almost negligible, but their perception by the synthetic community has changed in recent years and they are on their way to becoming mainstream. However, the hybridization of mechanochemical synthesis with methodologies designed to increase synthetic efficiency by allowing the generation of several bonds in a single operation has taken off only recently, but it already constitutes a very promising approach to sustainable chemistry. In this context, we provide in this Perspective a critical summary and discussion of the main known synthetic methods based on mechanochemical multicomponent reactions.

Graphical abstract: Multicomponent mechanochemical synthesis

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Article information

18 Dec 2017
28 Jan 2018
First published
29 Jan 2018

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2018,9, 2042-2064
Article type

Multicomponent mechanochemical synthesis

M. Leonardi, M. Villacampa and J. C. Menéndez, Chem. Sci., 2018, 9, 2042
DOI: 10.1039/C7SC05370C

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