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Issue 9, 2018
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Intra-mitochondrial biomineralization for inducing apoptosis of cancer cells

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Abstract

The use of biomineralization that regulates cellular functions has emerged as a potential therapeutic tool. However, the lack of selectivity still limits its therapeutic efficacy. Here, we report a subcellular-targeting biomineralization system featuring a triphenylphosphonium cation (TPP) (the mitochondria-targeting moiety) and trialkoxysilane (the biomineralization moiety via silicification). The TPP-containing trialkoxysilane exhibited approximately seven times greater cellular uptake into cancer cells (SCC7) than into normal cells (HEK293T) due to the more negative mitochondrial membrane potentials of the cancer cells. In turn, its accumulation inside mitochondria (pH 8) induces specific silicification, leading to the formation of silica particles in the mitochondrial matrix and further activation of apoptosis. In vivo assessment confirmed that the biomineralization system efficiently inhibits tumor growth in a mouse xenograft cancer model. Exploiting both the subcellular specificity and the targeting strategy provides new insight into the use of intracellular biomineralization for targeted cancer therapy.

Graphical abstract: Intra-mitochondrial biomineralization for inducing apoptosis of cancer cells

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Supplementary files

Article information


Submitted
06 Dec 2017
Accepted
24 Jan 2018
First published
25 Jan 2018

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2018,9, 2474-2479
Article type
Edge Article

Intra-mitochondrial biomineralization for inducing apoptosis of cancer cells

S. Kim, L. Palanikumar, H. Choi, M. T. Jeena, C. Kim and J. Ryu, Chem. Sci., 2018, 9, 2474
DOI: 10.1039/C7SC05189A

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    [Original citation] - Published by The Royal Society of Chemistry.

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