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Issue 6, 2018
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sp3 C–H activation via exo-type directing groups

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Abstract

The application of exo-type directing groups (DGs) has led to the discovery of a wide range of novel C(sp3)–H activation methods, which allow efficient and site-selective functionalization of alcohol and amide derivatives. In this mini-review we discuss the challenges of this field and summarize the achievements, including DG designs, reaction discoveries and mechanistic studies.

Graphical abstract: sp3 C–H activation via exo-type directing groups

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Article information


Submitted
04 Nov 2017
Accepted
02 Jan 2018
First published
17 Jan 2018

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2018,9, 1424-1432
Article type
Minireview

sp3 C–H activation via exo-type directing groups

Y. Xu and G. Dong, Chem. Sci., 2018, 9, 1424
DOI: 10.1039/C7SC04768A

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