Jump to main content
Jump to site search

Issue 8, 2018
Previous Article Next Article

Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa

Author affiliations

Abstract

The opportunistic human pathogen Pseudomonas aeruginosa secretes 2-heptyl-3-hydroxy-4-quinolone (PQS), a quorum sensing (QS) signal that regulates the expression of numerous virulence genes. Here we report the development and application of chemical probes to globally map quinolone binding proteins. The revealed quinolone interactome contains both known as well as newly identified virulence factors and presents new targets for the treatment of bacterial infections.

Graphical abstract: Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa

Back to tab navigation

Supplementary files

Article information


Submitted
02 Oct 2017
Accepted
19 Jan 2018
First published
19 Jan 2018

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2018,9, 2290-2294
Article type
Edge Article

Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa

R. Dandela, D. Mantin, B. F. Cravatt, J. Rayo and Michael M. Meijler, Chem. Sci., 2018, 9, 2290
DOI: 10.1039/C7SC04287F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements