Issue 3, 2018

Direct sulfonylation of anilines mediated by visible light


Sulfones feature prominently in biologically active molecules and are key functional groups for organic synthesis. We report a mild, photoredox-catalyzed reaction for sulfonylation of aniline derivatives with sulfinate salts, and demonstrate the utility of the method by the late-stage functionalization of drugs. Key features of the method are the straightforward generation of sulfonyl radicals from bench-stable sulfinate salts and the use of simple aniline derivatives as convenient readily available coupling partners.

Graphical abstract: Direct sulfonylation of anilines mediated by visible light

Supplementary files

Article information

Article type
Edge Article
05 Sep 2017
07 Nov 2017
First published
16 Nov 2017
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2018,9, 629-633

Direct sulfonylation of anilines mediated by visible light

T. C. Johnson, Bryony L. Elbert, A. J. M. Farley, T. W. Gorman, C. Genicot, B. Lallemand, P. Pasau, J. Flasz, J. L. Castro, M. MacCoss, D. J. Dixon, R. S. Paton, C. J. Schofield, M. D. Smith and M. C. Willis, Chem. Sci., 2018, 9, 629 DOI: 10.1039/C7SC03891G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity