Jump to main content
Jump to site search

Issue 2, 2019
Previous Article Next Article

Integrating reactive distillation with continuous flow processing

Author affiliations

Abstract

A continuous flow platform has been developed that integrates reactive distillation with modern flow reactor technology. This has been applied to the successful flow synthesis of a series of tetrahydroquinolines generated through an InCl3-catalysed Povarov reaction between different aryl imines and cyclopentadiene that was generated by a continuous distillation from its dimeric precursor via a thermal retro Diels–Alder reaction. The developed continuous process represents a robust approach to these important heterocyclic entities which were prepared on the gram scale within less than one hour.

Graphical abstract: Integrating reactive distillation with continuous flow processing

Back to tab navigation

Supplementary files

Article information


Submitted
28 Sep 2018
Accepted
30 Nov 2018
First published
30 Nov 2018

React. Chem. Eng., 2019,4, 368-371
Article type
Paper

Integrating reactive distillation with continuous flow processing

M. Baumann, React. Chem. Eng., 2019, 4, 368
DOI: 10.1039/C8RE00217G

Social activity

Search articles by author

Spotlight

Advertisements