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Integrating reactive distillation with continuous flow processing

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Abstract

A continuous flow platform has been developed that integrates reactive distillation with modern flow reactor technology. This has been applied to the successful flow synthesis of a series of tetrahydroquinolines generated through an InCl3-catalysed Povarov reaction between different aryl imines and cyclopentadiene that was generated by a continuous distillation from its dimeric precursor via a thermal retro Diels–Alder reaction. The developed continuous process represents a robust approach to these important heterocyclic entities which were prepared on the gram scale within less than one hour.

Graphical abstract: Integrating reactive distillation with continuous flow processing

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Publication details

The article was received on 28 Sep 2018, accepted on 30 Nov 2018 and first published on 30 Nov 2018


Article type: Paper
DOI: 10.1039/C8RE00217G
Citation: React. Chem. Eng., 2019, Advance Article
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    Integrating reactive distillation with continuous flow processing

    M. Baumann, React. Chem. Eng., 2019, Advance Article , DOI: 10.1039/C8RE00217G

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