Jump to main content
Jump to site search

Issue 5, 2018
Previous Article Next Article

A versatile, immobilized gold catalyst for the reductive amination of aldehydes in batch and flow

Author affiliations

Abstract

An efficient and environmentally friendly catalytic route for the reductive amination of carbonyl compounds has been designed. First, a one-pot procedure has been followed for the synthesis and incorporation of gold nanoparticles (AuNPs) into a mesoporous silica solid by using light as an abundant and clean energy source. Then, the as-prepared material has been successfully employed as a heterogeneous catalyst in the production of secondary and tertiary amines by reductive amination using Ph(Me)2SiH as the reducing agent. The endurance of the catalyst has been demonstrated in batch, and a continuous flow process allowing the safe preparation of multigram amounts of reductive amination products (accumulated TON = 434 in 18 h operation involving 6 sequential examples) has been implemented. The scope of the reaction has also been extended to the synthesis of more challenging active pharmaceutical ingredients (APIs), such as indoprofen precursors and biomass-derived products, which were obtained in good to excellent yields.

Graphical abstract: A versatile, immobilized gold catalyst for the reductive amination of aldehydes in batch and flow

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 Jun 2018, accepted on 10 Jul 2018 and first published on 13 Jul 2018


Article type: Paper
DOI: 10.1039/C8RE00101D
Citation: React. Chem. Eng., 2018,3, 714-721
  •   Request permissions

    A versatile, immobilized gold catalyst for the reductive amination of aldehydes in batch and flow

    A. I. Carrillo, P. Llanes and M. A. Pericàs, React. Chem. Eng., 2018, 3, 714
    DOI: 10.1039/C8RE00101D

Search articles by author

Spotlight

Advertisements