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Issue 5, 2018
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Integrated plug flow synthesis and crystallisation of pyrazinamide

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Abstract

We report the integration of flow chemistry with plug flow crystallisation. Catalytic flow hydration of pyrazinecarbonitrile to pyrazinamide was performed in a packed bed column of MnO2. The effluent of this flow reactor was directly linked to a tri-segmented tubular crystalliser (KRAIC), providing a seamless transition from flow synthesis to crystallisation, with control over solid form and particle characteristics.

Graphical abstract: Integrated plug flow synthesis and crystallisation of pyrazinamide

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Publication details

The article was received on 19 May 2018, accepted on 03 Jul 2018 and first published on 10 Jul 2018


Article type: Communication
DOI: 10.1039/C8RE00087E
Citation: React. Chem. Eng., 2018,3, 631-634
  • Open access: Creative Commons BY license
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    Integrated plug flow synthesis and crystallisation of pyrazinamide

    C. D. Scott, R. Labes, M. Depardieu, C. Battilocchio, M. G. Davidson, S. V. Ley, C. C. Wilson and K. Robertson, React. Chem. Eng., 2018, 3, 631
    DOI: 10.1039/C8RE00087E

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