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Issue 1, 2018
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Statistics of the network of organic chemistry

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Abstract

Organic chemistry can be represented as a network of reactions and studied by mathematical tools of graph theory. In this paper, the structure of a network of organic reactions has been studied using several graph theory metrics. The network was based on a section of chemical space downloaded from Reaxys. The studied area of chemistry corresponds to the chemistry of terpenes and includes 12 238 931 species and 12 939 422 reactions after filtering of an initial set of 35 million reactions. The analysis of the network statistics confirmed that the network was scale-free, as was reported in the earlier literature from the analysis of a much smaller network. Many networks in other technological or non-technological areas show that nodes have a preference as to whether they connect to highly connected or scarcely connected nodes, but for chemistry no such trend was observed. It was found that the network of reactions exhibits “small world” behaviour and in simile to the ‘six degrees of separation’ encountered in social networks, on average, any molecule could be made from any other molecule in six synthesis steps. Scale-free networks have hubs in their wiring pattern. By investigating whether these hubs are not only well studied but also frequently used, it was found that they concentrated a large share of the network's load onto themselves, showing that the network's structure impacts the usage of chemistry, or vice versa, implying a hierarchy of molecules.

Graphical abstract: Statistics of the network of organic chemistry

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Publication details

The article was received on 23 Aug 2017, accepted on 21 Dec 2017 and first published on 19 Jan 2018


Article type: Paper
DOI: 10.1039/C7RE00129K
React. Chem. Eng., 2018,3, 102-118
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    Statistics of the network of organic chemistry

    P. Jacob and A. Lapkin, React. Chem. Eng., 2018, 3, 102
    DOI: 10.1039/C7RE00129K

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