Issue 70, 2018, Issue in Progress

Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes

Abstract

A three-dimensional conjugated oligoelectrolyte (COE) bearing a [2.2]paracyclophane unit (COE2-3-pCp) was synthesized. Its biological activity was determined both in vivo and in silico within the context of membrane perturbation and biocompatibility. Molecular dynamics simulations indicate that, compared to its linear analog (COE2-3C), COE2-3-pCp introduces more lipid disorder with higher extent of membrane thinning. COE2-3-pCp also exhibits a higher MIC towards E. coli K12 and yeast, while maintaining similar levels of membrane permeabilization. These findings suggest a new design of COEs as biocompatible cell permeabilizers.

Graphical abstract: Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes

Supplementary files

Article information

Article type
Paper
Submitted
28 Sep 2018
Accepted
14 Nov 2018
First published
29 Nov 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 39849-39853

Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes

J. Limwongyut, Y. Liu, G. S. Chilambi, T. Seviour, J. Hinks, Y. Mu and G. C. Bazan, RSC Adv., 2018, 8, 39849 DOI: 10.1039/C8RA08069K

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