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Issue 68, 2018
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Bufalin suppresses colorectal cancer cell growth through promoting autophagy in vivo and in vitro

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Abstract

Specific groups in Asia, including the Chinese, are more susceptible to colorectal cancer (CRC). The best strategy for anticancer drug action is to induce cancer cell apoptosis and autophagy. Bufalin is a potent inducer of apoptosis in some human cancer cell lines, but bufalin has barely been evaluated in colorectal cancer cells as a potent autophagy inducing agent. The aim of this study was to investigate the roles and interactions of bufalin in autophagy and the effects of the drug on human colorectal cancer. We applied bufalin and autophagy inhibitors (CQ and 3-MA) in LoVo cells to investigate their potential anticancer bioactivity under certain concentrations of bufalin to monitor autophagy and cell proliferation in vivo and in vitro. Bufalin induced autophagy of LoVo and inhibited proliferation of LoVo cells. Bufalin inhibited the expression of autophagy-related (ATG) proteins and tumor growth in vivo. Our studies identified that bufalin could potentially be a small molecule inhibitor for cancer therapy.

Graphical abstract: Bufalin suppresses colorectal cancer cell growth through promoting autophagy in vivo and in vitro

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Article information


Submitted
04 Aug 2018
Accepted
06 Nov 2018
First published
19 Nov 2018

This article is Open Access

RSC Adv., 2018,8, 38910-38918
Article type
Paper

Bufalin suppresses colorectal cancer cell growth through promoting autophagy in vivo and in vitro

Z. Pan, Y. Xie, J. Bai, Q. Lin, X. Cui and N. Zhang, RSC Adv., 2018, 8, 38910
DOI: 10.1039/C8RA06566G

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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    [Original citation] - Published by The Royal Society of Chemistry.

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