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Issue 50, 2018, Issue in Progress
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The sustainable synthesis of peptidomimetics via chemoenzymatic tandem oxidation–Ugi reaction

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Abstract

A simply and green synthetic protocol based on the selective laccase-oxidation of alcohol to a corresponding aldehyde and a following Ugi reaction in a micellar system made of SDS was developed and is reported herein. Special emphasis was placed on the metal-free chemoenzymatic tandem reaction based on alcohol oxidation strategies using molecular oxygen from air, followed by an Ugi reaction. The reaction was carried out without the use of a transition metal or organic solvents as a reaction medium. The presented protocol offers an efficient and environmentally friendly procedure.

Graphical abstract: The sustainable synthesis of peptidomimetics via chemoenzymatic tandem oxidation–Ugi reaction

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Publication details

The article was received on 29 May 2018, accepted on 26 Jul 2018 and first published on 08 Aug 2018


Article type: Paper
DOI: 10.1039/C8RA04583F
RSC Adv., 2018,8, 28405-28413
  • Open access: Creative Commons BY-NC license
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    The sustainable synthesis of peptidomimetics via chemoenzymatic tandem oxidation–Ugi reaction

    A. Madej, D. Koszelewski, D. Paprocki, A. Brodzka and R. Ostaszewski, RSC Adv., 2018, 8, 28405
    DOI: 10.1039/C8RA04583F

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