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Issue 64, 2018, Issue in Progress
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Total synthesis of μ-conotoxin lt5d

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Abstract

The total synthesis of μ-conotoxin lt5d is presented for the first time employing two different strategies. One involves glutathione-assisted oxidation where all disulphide linkages are formed simultaneously. Another involves orthogonal protection of cysteine residues, allowing the controlled formation of disulphide linkages sequentially. Both methods achieve the same peptide.

Graphical abstract: Total synthesis of μ-conotoxin lt5d

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Article information


Submitted
30 Apr 2018
Accepted
23 Oct 2018
First published
30 Oct 2018

This article is Open Access

RSC Adv., 2018,8, 36579-36583
Article type
Paper

Total synthesis of μ-conotoxin lt5d

A. M. B. Naraga, O. J. V. Belleza and A. J. L. Villaraza, RSC Adv., 2018, 8, 36579
DOI: 10.1039/C8RA03706J

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