Total synthesis of μ-conotoxin lt5d†
A. M. B.
Naraga, 
a
O. J. V.
Belleza
a
and
a
O. J. V.
Belleza
a
and
Abstract
The total synthesis of μ-conotoxin lt5d is presented for the first time employing two different strategies. One involves glutathione-assisted oxidation where all disulphide linkages are formed simultaneously. Another involves orthogonal protection of cysteine residues, allowing the controlled formation of disulphide linkages sequentially. Both methods achieve the same peptide.
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