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Issue 40, 2018, Issue in Progress
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Nano-engineering safer-by-design nanoparticle based moth-eye mimetic bactericidal and cytocompatible polymer surfaces

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Abstract

Nanotechnology provides a new design paradigm for alternative antibacterial strategies in the fight against drug-resistant bacteria. In this paper, the enhanced bactericidal action of moth-eye nanocomposite surfaces with a collaborative nanoparticle functional and topography structural mode of action is reported. The moth-eye nanocomposite surfaces are fabricated in combined processing steps of nanoparticle coating and surface nanoimprinting enabling the production of safer-by-design nanoparticle based antibacterial materials whereby the nanoparticle load is minimized whilst bactericidal efficiency is improved. The broad antibacterial activity of the nanocomposite moth-eye topographies is demonstrated against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli and Pseudomonas aeruginosa as model bacteria. The antibacterial performance of the moth-eye nanocomposite topographies is notably improved over that of the neat moth-eye surfaces with bacteria inhibition efficiencies up to 90%. Concurrently, the moth-eye nanocomposite topographies show a non-cytotoxic behaviour allowing for the normal attachment and proliferation of human keratinocytes.

Graphical abstract: Nano-engineering safer-by-design nanoparticle based moth-eye mimetic bactericidal and cytocompatible polymer surfaces

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Publication details

The article was received on 20 Apr 2018, accepted on 10 Jun 2018 and first published on 20 Jun 2018


Article type: Paper
DOI: 10.1039/C8RA03403F
RSC Adv., 2018,8, 22606-22616
  • Open access: Creative Commons BY license
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    Nano-engineering safer-by-design nanoparticle based moth-eye mimetic bactericidal and cytocompatible polymer surfaces

    F. Viela, I. Navarro-Baena, A. Jacobo-Martín, J. J. Hernández, M. Boyano-Escalera, M. R. Osorio and I. Rodríguez, RSC Adv., 2018, 8, 22606
    DOI: 10.1039/C8RA03403F

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