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Issue 26, 2018
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Trifluoromethylated proline analogues as efficient tools to enhance the hydrophobicity and to promote passive diffusion transport of the l-prolyl-l-leucyl glycinamide (PLG) tripeptide

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Abstract

The synthesis of four CF3-proline analogues of the PLG peptide is reported. Our results show that the incorporation of trifluoromethylated amino acids (Tfm-AAs) at the N-terminal position of a peptide significantly increases its hydrophobicity. In addition, depending on the relative configuration and the position of the CF3 group, Tfm-AAs can also promote passive diffusion transport.

Graphical abstract: Trifluoromethylated proline analogues as efficient tools to enhance the hydrophobicity and to promote passive diffusion transport of the l-prolyl-l-leucyl glycinamide (PLG) tripeptide

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Article information


Submitted
22 Mar 2018
Accepted
11 Apr 2018
First published
18 Apr 2018

This article is Open Access

RSC Adv., 2018,8, 14597-14602
Article type
Paper

Trifluoromethylated proline analogues as efficient tools to enhance the hydrophobicity and to promote passive diffusion transport of the L-prolyl-L-leucyl glycinamide (PLG) tripeptide

M. Oliver, C. Gadais, J. García-Pindado, M. Teixidó, N. Lensen, G. Chaume and T. Brigaud, RSC Adv., 2018, 8, 14597
DOI: 10.1039/C8RA02511H

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