Issue 29, 2018, Issue in Progress

An efficient and green approach for the synthesis of 2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates using Bi2O3/ZrO2 as a reusable catalyst

Abstract

A novel material of bismuth loaded on zirconia (Bi2O3/ZrO2) is synthesized by simple wet-impregnation method and characterized by several techniques (P-XRD, TEM, SEM, BET, etc.). Bi2O3/ZrO2 proved to be a good catalyst for the four-component, one-pot reaction to produce a new series of 2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylate derivatives with excellent yields (91 to 98%) under mild conditions at RT with short reaction times (≈20 min). The structures of the target molecules were confirmed by 1H NMR, 13C NMR, 15N NMR, HRMS and FT-IR. The catalyst is easily separable and can be reused for six cycles without ostensible loss of activity. This method is inexpensive, atom-efficient and no chromatographic separations are needed.

Graphical abstract: An efficient and green approach for the synthesis of 2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates using Bi2O3/ZrO2 as a reusable catalyst

Supplementary files

Article information

Article type
Paper
Submitted
06 Mar 2018
Accepted
23 Apr 2018
First published
03 May 2018
This article is Open Access
Creative Commons BY license

RSC Adv., 2018,8, 16336-16343

An efficient and green approach for the synthesis of 2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates using Bi2O3/ZrO2 as a reusable catalyst

Sandeep V. H. S. Bhaskaruni, S. Maddila, W. E. van Zyl and S. B. Jonnalagadda, RSC Adv., 2018, 8, 16336 DOI: 10.1039/C8RA01994K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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