ACI/EG eutectic mixture mediated synthesis, characterization and in vitro osteoblast differentiation assessment of spiropyrrolo[1,2-b]isoquinoline analogues

Govindasami Periyasami; Natarajan Arumugam; Mostafizur Rahaman; Raju Suresh Kumar; Muthurangan Manikandan; Musaad A. Alfayez; Dhanaraj Premnath; Ali Aldalbahi

doi:10.1039/C8RA00646F

ACI/EG eutectic mixture mediated synthesis, characterization and in vitro osteoblast differentiation assessment of spiropyrrolo[1,2-b]isoquinoline analogues†

Govindasami Periyasami,

*^ab Natarajan Arumugam,

^a Mostafizur Rahaman,^a Raju Suresh Kumar,^a Muthurangan Manikandan,^c Musaad A. Alfayez,^c Dhanaraj Premnath^d and Ali Aldalbahi*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
E-mail: aaldalbahi@ksu.edu.sa, pkandhan@ksu.edu.sa

^b Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India

^c Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia

^d Department of Oral Biology, Dentistry Building-D325, Winnipeg, Manitoba, Canada

Abstract

An eco-friendly acetylcholine iodide–ethylene glycol (ACI/EG) deep eutectic mixture mediated green protocol has been developed for the synthesis of hitherto unexplored multi-functionalized linear tricyclic spiropyrrolo[1,2-b]isoquinoline analogues. The effects of the synthesized compounds on the osteoblast differentiation of hBMSC-TERT cell lines were investigated and promising results were observed with significant IC₅₀ values. In addition, molecular modeling simulations were also performed with the 3D structure of BMP-2 to reveal binding interactions and orientations of highly potent spiropyrrolo[1,2-b]isoquinoline analogues.

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DOI: https://doi.org/10.1039/C8RA00646F
Article type: Paper
Submitted: 22 Jan 2018
Accepted: 13 Apr 2018
First published: 02 May 2018
This article is Open Access

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RSC Adv., 2018,8, 16303-16313

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ACI/EG eutectic mixture mediated synthesis, characterization and in vitro osteoblast differentiation assessment of spiropyrrolo[1,2-b]isoquinoline analogues

G. Periyasami, N. Arumugam, M. Rahaman, R. S. Kumar, M. Manikandan, M. A. Alfayez, D. Premnath and A. Aldalbahi, RSC Adv., 2018, 8, 16303 DOI: 10.1039/C8RA00646F

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ACI/EG eutectic mixture mediated synthesis, characterization and in vitro osteoblast differentiation assessment of spiropyrrolo[1,2-b]isoquinoline analogues†

Abstract

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ACI/EG eutectic mixture mediated synthesis, characterization and in vitro osteoblast differentiation assessment of spiropyrrolo[1,2-b]isoquinoline analogues

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