Issue 21, 2018
From the journal:

RSC Advances

A novel glutathione-triggered theranostic prodrug for anticancer and imaging in living cells†

Hengrui Zhanga  and  Zhijie Fang ORCID logo *a  

* Corresponding authors

a School of Chemical Engineering, Nanjing University of Science & Technology, 200 Xiao Ling Wei, Nanjing 210094, P. R. China
E-mail: zjfang@njust.edu.cn

Abstract

A novel theranostic prodrug was designed and synthesized by conjugating a naphthalimide derivative with vitamin D2 via a disulfide linker. The prodrug featured a highly selective detection process for glutathione (GSH) and showed a red-shifted fluorescence within 30 min. Notably, it also exhibited antitumor activity similar to vitamin D2 and could be monitored by cellular imaging.

Graphical abstract: A novel glutathione-triggered theranostic prodrug for anticancer and imaging in living cells

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Article information

DOI
https://doi.org/10.1039/C8RA00271A
Article type
Paper
Submitted
10 Jan 2018
Accepted
07 Mar 2018
First published
22 Mar 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 11419-11423

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A novel glutathione-triggered theranostic prodrug for anticancer and imaging in living cells

H. Zhang and Z. Fang, RSC Adv., 2018, 8, 11419 DOI: 10.1039/C8RA00271A

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