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Issue 13, 2018, Issue in Progress
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Antioxidant and anti-inflammatory effects of polyphenols extracted from Ilex latifolia Thunb

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Abstract

To promote the rational and effective application of Ilex latifolia Thunb., a Chinese bitter tea widely consumed as a health beverage, polyphenols were extracted from its leaves and their cellular antioxidant activity (CAA) and anti-inflammatory effect against mouse macrophage RAW 264.7 cells were analyzed. Results showed that the antioxidant capacity of polyphenols was high, and their CAA values in PBS wash and no PBS wash protocols were 6871.42 ± 85.56 and 25161.61 ± 583.55 μmol QE (quercetin equivalents)/100 g phenolic extracts, respectively. In addition, polyphenols from I. latifolia displayed strong inhibition on LPS-induced NO-production in RAW 264.7 cells. Polyphenol treatment inhibited the release of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) induced by LPS in a dose-dependent manner by ELISA and mRNA expression analysis. Western blot results showed that the anti-inflammatory activity of polyphenols from I. latifolia might be exerted through inhibiting the activation of MAPKs (ERK and JNK) and NF-κB to decrease NO, COX-2 and pro-inflammatory cytokines production. Thus, the polyphenol enriched extracts from I. latifolia are a good source of natural antioxidants with a beneficial effect against inflammation, and they may be applied as a food supplement and/or functional ingredient.

Graphical abstract: Antioxidant and anti-inflammatory effects of polyphenols extracted from Ilex latifolia Thunb

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Article information


Submitted
22 Dec 2017
Accepted
05 Feb 2018
First published
14 Feb 2018

This article is Open Access

RSC Adv., 2018,8, 7134-7141
Article type
Paper

Antioxidant and anti-inflammatory effects of polyphenols extracted from Ilex latifolia Thunb

T. Zhang, T. Hu, J. Jiang, J. Zhao and W. Zhu, RSC Adv., 2018, 8, 7134
DOI: 10.1039/C7RA13569F

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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    [Original citation] - Published by The Royal Society of Chemistry.

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