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Issue 10, 2018, Issue in Progress
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Synthesis of CHF2-substituted 3-azabicyclo[3.1.0]hexanes by photochemical decomposition of CHF2-pyrazolines

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Abstract

A practical synthesis of CHF2-substituted 3-azabicyclo[3.1.0]hexanes was developed for the first time. The key step was photochemical decomposition of CHF2-substituted pyrazolines. This protocol has the advantages of simple operation, and mild conditions, as well as excellent functional group tolerance, giving the desired products in moderate to excellent yields.

Graphical abstract: Synthesis of CHF2-substituted 3-azabicyclo[3.1.0]hexanes by photochemical decomposition of CHF2-pyrazolines

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Publication details

The article was received on 08 Dec 2017, accepted on 23 Jan 2018 and first published on 29 Jan 2018


Article type: Paper
DOI: 10.1039/C7RA13141K
Citation: RSC Adv., 2018,8, 5114-5118
  • Open access: Creative Commons BY-NC license
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    Synthesis of CHF2-substituted 3-azabicyclo[3.1.0]hexanes by photochemical decomposition of CHF2-pyrazolines

    Y. Zheng, X. Yu, S. Lv, P. K. Mykhailiuk, Q. Ma, L. Hai and Y. Wu, RSC Adv., 2018, 8, 5114
    DOI: 10.1039/C7RA13141K

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