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Issue 10, 2018
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An innovative small molecule for promoting neuroreparative strategies

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Abstract

In this study, a new regenerative strategy to treat several neurodegenerative diseases is suggested by the use of a multitarget approach induced by our small molecule, MC111. Considering the importance of P-gp and BCRP expression on stem cell differentiation and the involvement of TLR4 on neurodegeneration processes, we investigated the effect of MC111, belonging to our library of P-gp active compounds on: (i) TLR4 signaling; (ii) P-gp and BCRP activity and expression; (iii) neurite sprouting. The observed findings exerted by MC111, open a new scenario for a multitarget and regenerative approach in neurodegenerative diseases encouraging the in vivo evaluation of MC111 as new tool in neuroreparative medicine.

Graphical abstract: An innovative small molecule for promoting neuroreparative strategies

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Article information


Submitted
26 Oct 2017
Accepted
22 Jan 2018
First published
31 Jan 2018

This article is Open Access

RSC Adv., 2018,8, 5451-5458
Article type
Paper

An innovative small molecule for promoting neuroreparative strategies

N. A. Colabufo, M. Contino, M. Cantore, F. Berardi, R. Perrone, A. Tonazzi, L. Console, M. A. Panaro, H. Savolainen and G. Luurtsema, RSC Adv., 2018, 8, 5451
DOI: 10.1039/C7RA11812K

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