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Issue 12, 2018, Issue in Progress
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Structure and characterisation of hydroxyethylcellulose–silica nanoparticles

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Abstract

Functionalising nanoparticles with polymers has gained much interest in recent years, as it aids colloidal stability and manipulation of surface properties. Here, polymer-coated thiolated silica nanoparticles were synthesised by self-condensation of 3-mercaptopropyltrimethoxysilane in the presence of hydroxyethylcellulose. These nanoparticles were characterised by dynamic light scattering, small angle neutron scattering, Nanoparticle Tracking Analysis, Raman spectroscopy, FT-IR spectroscopy, thermogravimetric analysis, Ellman's assay, transmission electron microscopy and cryo-transmission electron microscopy. It was found that increasing the amount of hydroxyethylcellulose in the reaction mixture increased the nanoparticle size and reduced the number of thiol groups on their surface. Additionally, by utilising small angle neutron scattering and dynamic light scattering, it was demonstrated that higher concentrations of polymer in the reaction mixture (0.5–2% w/v) resulted in the formation of aggregates, whereby several silica nanoparticles are bridged together with macromolecules of hydroxyethylcellulose. A correlation was identified between the aggregate size and number of particles per aggregate based on size discrepancies observed between DLS and SANS measurements. This information makes it possible to control the size of aggregates during a simple one-pot synthesis; a prospect highly desirable in the design of potential drug delivery systems.

Graphical abstract: Structure and characterisation of hydroxyethylcellulose–silica nanoparticles

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Supplementary files

Article information


Submitted
07 Aug 2017
Accepted
29 Jan 2018
First published
08 Feb 2018

This article is Open Access

RSC Adv., 2018,8, 6471-6478
Article type
Paper

Structure and characterisation of hydroxyethylcellulose–silica nanoparticles

E. D. H. Mansfield, Y. Pandya, E. A. Mun, S. E. Rogers, I. Abutbul-Ionita, D. Danino, A. C. Williams and V. V. Khutoryanskiy, RSC Adv., 2018, 8, 6471
DOI: 10.1039/C7RA08716K

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