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Issue 1, 2018
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Paclitaxel prodrug based mixed micelles for tumor-targeted chemotherapy

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Abstract

An effective chemotherapy is usually subject to an insufficient loading of hydrophobic drugs as well as severe side effects. In order to address these dilemmas in one formulation, we herein construct paclitaxel prodrug based mixed micelles (MMs) for tumor-targeted chemotherapy. The paclitaxel prodrug containing a hydrophobic PTX and a hydrophilic PEG chain can self-assemble into uniform MMs with distearoyl phosphoethanolamine–polyethylene glycol–folate (DSPE–PEG–FA). The resultant MMs with preferable stability and hemolysis compatibility could improve the cellular uptake of nanoparticles via FA receptor-mediated endocytosis as compared to the single micelles (SMs). This tumor targetability was also confirmed in vivo by fluorescent imaging. MMs with a stable drug loading as well as tumor targetability displayed elevated in vitro cytotoxicity and in vivo antitumor efficacy compared with Taxol, which could be a potential formulation for cancer therapy.

Graphical abstract: Paclitaxel prodrug based mixed micelles for tumor-targeted chemotherapy

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Publication details

The article was received on 15 Jul 2017, accepted on 01 Dec 2017 and first published on 02 Jan 2018


Article type: Paper
DOI: 10.1039/C7RA07796C
RSC Adv., 2018,8, 380-389
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    Paclitaxel prodrug based mixed micelles for tumor-targeted chemotherapy

    D. Tang, X. Zhao, T. Yang and C. Wang, RSC Adv., 2018, 8, 380
    DOI: 10.1039/C7RA07796C

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