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Cross-dehydrogenative alkynylation of sulfonamides and amides with terminal alkynes via Ir(III) catalysis

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Abstract

Primary sulfonamides are widely used structural skeletons in bioactive molecules, however their direct modification via C–H functionalization remains to be developed. Herein, direct cross-dehydrogenative C–H alkynylations of amides and primary sulfonamides with terminal alkynes is reported. This general process features predictable regioselectivity towards multiple functionalized arenes and the stereoselective generation of tetrasubstituted olefins, which might provide insight into the expedient delivery of related bioactive and material molecules.

Graphical abstract: Cross-dehydrogenative alkynylation of sulfonamides and amides with terminal alkynes via Ir(iii) catalysis

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Publication details

The article was received on 15 Oct 2018, accepted on 31 Oct 2018 and first published on 01 Nov 2018


Article type: Research Article
DOI: 10.1039/C8QO01105B
Citation: Org. Chem. Front., 2018, Advance Article
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    Cross-dehydrogenative alkynylation of sulfonamides and amides with terminal alkynes via Ir(III) catalysis

    G. Wu, W. Ouyang, Q. Chen, Y. Huo and X. Li, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C8QO01105B

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