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Issue 23, 2018
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Ni-Catalyzed 1,2-iminoacylation of alkenes via a reductive strategy

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Abstract

In this protocol, we developed a reductive strategy for 1,2-iminoacylation of alkenes. Under the catalysis of the Ni-biquinoline system, various oxime esters incorporating a pendant terminal olefinic unit were successfully reacted with acid chlorides or anhydrides as electrophilic acylating reagents in the presence of Zn as a reductant, furnishing a series of pyrrolines in moderate to excellent yields. This reaction is distinguished by safe and mild reaction conditions that avoid the use of CO gas as a carbonyl source, pregenerated organometallics and strong bases as reaction additives.

Graphical abstract: Ni-Catalyzed 1,2-iminoacylation of alkenes via a reductive strategy

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Publication details

The article was received on 27 Sep 2018, accepted on 23 Oct 2018 and first published on 25 Oct 2018


Article type: Research Article
DOI: 10.1039/C8QO01044G
Citation: Org. Chem. Front., 2018,5, 3476-3482

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    Ni-Catalyzed 1,2-iminoacylation of alkenes via a reductive strategy

    L. Wang and C. Wang, Org. Chem. Front., 2018, 5, 3476
    DOI: 10.1039/C8QO01044G

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