Jump to main content
Jump to site search


Ni-Catalyzed 1,2-iminoacylation of alkenes via a reductive strategy

Author affiliations

Abstract

In this protocol, we developed a reductive strategy for 1,2-iminoacylation of alkenes. Under the catalysis of the Ni-biquinoline system, various oxime esters incorporating a pendant terminal olefinic unit were successfully reacted with acid chlorides or anhydrides as electrophilic acylating reagents in the presence of Zn as a reductant, furnishing a series of pyrrolines in moderate to excellent yields. This reaction is distinguished by safe and mild reaction conditions that avoid the use of CO gas as a carbonyl source, pregenerated organometallics and strong bases as reaction additives.

Graphical abstract: Ni-Catalyzed 1,2-iminoacylation of alkenes via a reductive strategy

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Sep 2018, accepted on 23 Oct 2018 and first published on 25 Oct 2018


Article type: Research Article
DOI: 10.1039/C8QO01044G
Citation: Org. Chem. Front., 2018, Advance Article
  •   Request permissions

    Ni-Catalyzed 1,2-iminoacylation of alkenes via a reductive strategy

    L. Wang and C. Wang, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C8QO01044G

Search articles by author

Spotlight

Advertisements