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Issue 23, 2018
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Ring-opening and cyclization of aziridines with aryl azides: metal-free synthesis of 6-(triflyloxy)quinolines

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Abstract

Ring-opening and cyclization of aziridines with aryl azides in the presence of TfOH has been developed. This strategy enables the construction of 6-(triflyloxy)quinoline cores by utilizing aziridine as a two-carbon surrogate. The introduction of a trifyl group at the 6-position of quinoline would allow further construction of carbon–carbon and carbon–heteroatom bonds in the cross-coupling reactions.

Graphical abstract: Ring-opening and cyclization of aziridines with aryl azides: metal-free synthesis of 6-(triflyloxy)quinolines

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Publication details

The article was received on 10 Sep 2018, accepted on 23 Oct 2018 and first published on 25 Oct 2018


Article type: Research Article
DOI: 10.1039/C8QO00984H
Citation: Org. Chem. Front., 2018,5, 3488-3493
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    Ring-opening and cyclization of aziridines with aryl azides: metal-free synthesis of 6-(triflyloxy)quinolines

    R. Yi, X. Li and B. Wan, Org. Chem. Front., 2018, 5, 3488
    DOI: 10.1039/C8QO00984H

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