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Total Synthesis and Structure Revision of Chrysamides B

Abstract

Total synthesis of originally proposed chrysamides B (2) is described, featured a convergent assembly of chiral piperazine core and epoxy-acid. Mismatched spectroscopic data for synthetic sample compared to the isolate led us to propose the revised structure 3 based on biosynthetic considerations. In further antibacterial assay, chrysamides B and its diastereomer 2 exhibited different activity.

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Publication details

The article was received on 01 Sep 2018, accepted on 06 Oct 2018 and first published on 08 Oct 2018


Article type: Research Article
DOI: 10.1039/C8QO00949J
Citation: Org. Chem. Front., 2018, Accepted Manuscript
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    Total Synthesis and Structure Revision of Chrysamides B

    J. H. Chen, J. Li, L. Zhu, X. Peng, Y. Feng, Y. Lu, X. Hu, J. Liang, Q. Y. zhao and Z. Wang, Org. Chem. Front., 2018, Accepted Manuscript , DOI: 10.1039/C8QO00949J

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