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Issue 20, 2018
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Enantioselective access to multi-cyclic α-amino phosphonates via carbene-catalyzed cycloaddition reactions between enals and six-membered cyclic imines

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Abstract

A carbene-catalyzed enantioselective cycloaddition reaction between enals and cyclic ketiminophosphonates is disclosed. α-Amino phosphonates bearing sophisticated fused heterocycles and quaternary carbons are afforded with excellent enantioselectivities. The α-amino phosphonate products from our approach exhibit encouraging anti-bacterial activities against X. oryzae pv. oryzae, the bacteria that cause serious diseases to rice and other plants.

Graphical abstract: Enantioselective access to multi-cyclic α-amino phosphonates via carbene-catalyzed cycloaddition reactions between enals and six-membered cyclic imines

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Publication details

The article was received on 14 Aug 2018, accepted on 12 Sep 2018 and first published on 13 Sep 2018


Article type: Research Article
DOI: 10.1039/C8QO00877A
Citation: Org. Chem. Front., 2018,5, 2992-2996
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    Enantioselective access to multi-cyclic α-amino phosphonates via carbene-catalyzed cycloaddition reactions between enals and six-membered cyclic imines

    J. Sun, C. Mou, C. Liu, R. Huang, S. Zhang, P. Zheng and Y. R. Chi, Org. Chem. Front., 2018, 5, 2992
    DOI: 10.1039/C8QO00877A

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