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Base-promoted C–C bond cleavage for the synthesis of 2,3,4-trisubstituted pyrroles from N-propargyl β-enaminones

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Abstract

A base-promoted selective cleavage of an unstrained C(CO)–C(sp2) bond of N-propargyl β-enaminones under transition metal- and oxidant-free conditions has been established. This method allows the formation of a new C(sp2)–C(sp2) bond for the synthesis of 2,3,4-trisubstituted pyrroles under mild reaction conditions with broad functional group tolerance.

Graphical abstract: Base-promoted C–C bond cleavage for the synthesis of 2,3,4-trisubstituted pyrroles from N-propargyl β-enaminones

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Publication details

The article was received on 31 Jul 2018, accepted on 19 Sep 2018 and first published on 19 Sep 2018


Article type: Research Article
DOI: 10.1039/C8QO00801A
Citation: Org. Chem. Front., 2018, Advance Article
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    Base-promoted C–C bond cleavage for the synthesis of 2,3,4-trisubstituted pyrroles from N-propargyl β-enaminones

    B. Ge, W. Lv, J. Yu, S. Xiao and G. Cheng, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C8QO00801A

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