Iridium-catalyzed oxidative Ar–H/Ar–H cross-coupling of primary benzamides with thiophenes†
(2-Thienyl)benzamide frameworks are prevalent in pharmaceuticals and advanced materials. Herein, we disclose an iridium-catalyzed oxidative Ar–H/Ar–H cross-coupling reaction of primary benzamides with thiophenes, which provides a rapid pathway to (2-thienyl)benzamide skeletons. Furthermore, the coupled products can be transformed to the corresponding important thiophene-fused 1-isoquinolinones via a copper-catalyzed intramolecular annulation.
- This article is part of the themed collections: Celebrating the 90th birthday of Professor Lu Xiyan and Organic Chemistry Frontiers HOT articles for 2018