Jump to main content
Jump to site search

Issue 20, 2018
Previous Article Next Article

Iridium-catalyzed oxidative Ar–H/Ar–H cross-coupling of primary benzamides with thiophenes

Author affiliations

Abstract

(2-Thienyl)benzamide frameworks are prevalent in pharmaceuticals and advanced materials. Herein, we disclose an iridium-catalyzed oxidative Ar–H/Ar–H cross-coupling reaction of primary benzamides with thiophenes, which provides a rapid pathway to (2-thienyl)benzamide skeletons. Furthermore, the coupled products can be transformed to the corresponding important thiophene-fused 1-isoquinolinones via a copper-catalyzed intramolecular annulation.

Graphical abstract: Iridium-catalyzed oxidative Ar–H/Ar–H cross-coupling of primary benzamides with thiophenes

Back to tab navigation

Supplementary files

Publication details

The article was received on 31 Jul 2018, accepted on 06 Sep 2018 and first published on 06 Sep 2018


Article type: Research Article
DOI: 10.1039/C8QO00796A
Org. Chem. Front., 2018,5, 2930-2933

  •   Request permissions

    Iridium-catalyzed oxidative Ar–H/Ar–H cross-coupling of primary benzamides with thiophenes

    G. Tan, C. Ran and J. You, Org. Chem. Front., 2018, 5, 2930
    DOI: 10.1039/C8QO00796A

Search articles by author

Spotlight

Advertisements