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Issue 19, 2018
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Hydrofunctionalization of alkenols triggered by the addition of diverse radicals to unactivated alkenes and subsequent remote hydrogen atom translocation

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Abstract

Diverse anti-Markovnikov hydrofunctionalization of alkenols triggered by the addition of S-, P-, and C-centered radicals to alkenes followed by intramolecular 1,5(6)-hydrogen atom transfer (HAT) with remote α-C–H bonds of alcohols has been developed. The strategy simultaneously realized the hydrofunctionalization of alkenes and remote alcohol oxidation. This mild and versatile method allows for direct access to valuable sulfonyl-, phosphonyl-, and malonate-substituted ketones or aldehydes from a wide range of alkenols.

Graphical abstract: Hydrofunctionalization of alkenols triggered by the addition of diverse radicals to unactivated alkenes and subsequent remote hydrogen atom translocation

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Publication details

The article was received on 18 Jul 2018, accepted on 22 Aug 2018 and first published on 22 Aug 2018


Article type: Research Article
DOI: 10.1039/C8QO00734A
Org. Chem. Front., 2018,5, 2810-2814

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    Hydrofunctionalization of alkenols triggered by the addition of diverse radicals to unactivated alkenes and subsequent remote hydrogen atom translocation

    N. Wang, L. Ye, Z. Li, L. Li, Z. Li, H. Zhang, Z. Guo, Q. Gu and X. Liu, Org. Chem. Front., 2018, 5, 2810
    DOI: 10.1039/C8QO00734A

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