Hui Xu, Kuan Chen, Hong-Wei Liu and Guan-Wu Wang
Org. Chem. Front., 2018,5, 2864-2869
DOI:
10.1039/C8QO00723C,
Research Article
A novel N-iodosuccinimide-promoted intermolecular cyclization between alkenes and amidines has been demonstrated under solvent-free ball-milling conditions, affording a variety of spiroimidazolines with remarkable functional group tolerance and good to excellent yields. The present protocol features short reaction time, mild reaction conditions, high atom economy and feasibility of large-scale synthesis, providing an efficient and environmentally friendly access to spiroimidazolines.