Jump to main content
Jump to site search

Issue 16, 2018
Previous Article Next Article

Pd(II)-Catalyzed [3 + 2] spiroannulation of α-aryl-β-naphthols with alkynes via a C–H activation/dearomatization approach

Author affiliations

Abstract

Readily available α-aryl-β-naphthols undergo a [3 + 2] spiroannulation with internal alkynes upon treatment with a Pd(II) catalyst and an oxidant. This transformation involves sequential C–H activation, alkyne migratory insertion, and naphthol dearomatization, affording highly appealing spirocyclic molecules in high yields with good functional group tolerance. Preliminary results with chiral phosphoramidite ligands indicate that enantioselective variants are feasible for this process.

Graphical abstract: Pd(ii)-Catalyzed [3 + 2] spiroannulation of α-aryl-β-naphthols with alkynes via a C–H activation/dearomatization approach

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Jun 2018, accepted on 06 Jul 2018 and first published on 10 Jul 2018


Article type: Research Article
DOI: 10.1039/C8QO00614H
Citation: Org. Chem. Front., 2018,5, 2453-2457
  •   Request permissions

    Pd(II)-Catalyzed [3 + 2] spiroannulation of α-aryl-β-naphthols with alkynes via a C–H activation/dearomatization approach

    L. Han, H. Wang and X. Luan, Org. Chem. Front., 2018, 5, 2453
    DOI: 10.1039/C8QO00614H

Search articles by author

Spotlight

Advertisements