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Differential Calixarene Receptors Create Patterns that Discriminating Glycosaminoglycans

Abstract

On account of the challenge of discriminating glycosaminoglycans (GAGs) via optical methods, we design a fluorescent displacement sensing array. The sensing array is composed of four reporter pairs, where four positively charged calixarene derivatives act as the receptors, and eosin Y as the reporter dye. The complexation of calixarenes quenches the fluorescence of the dye, and thereby, the competitive complexation of analytes gives rise to the fluorescence regeneration, achieving the switch-on sensing. By implementing indicator displacement assay of four reporter pairs towards six GAGs, we obtained the fluorescence response patterns for each GAG. The subsequent chemometric analyses make the fluorescence discrimination of GAGs well realized. Besides the sensing selectivity, the present reporter pairs also exhibit high sensitivity.

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Publication details

The article was received on 21 Jun 2018, accepted on 08 Aug 2018 and first published on 09 Aug 2018


Article type: Research Article
DOI: 10.1039/C8QO00606G
Citation: Org. Chem. Front., 2018, Accepted Manuscript
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    Differential Calixarene Receptors Create Patterns that Discriminating Glycosaminoglycans

    Z. Zheng, W. Geng, J. Gao, Y. Mu and D. Guo, Org. Chem. Front., 2018, Accepted Manuscript , DOI: 10.1039/C8QO00606G

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