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Issue 16, 2018
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A facile synthesis of diverse 5-arylated triazoles via a Cu-catalyzed oxidative interrupted click reaction with arylboronic acids in air

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Abstract

We herein disclose a Cu-catalyzed synthesis of 5-arylsubstituted 1,2,3-triazoles via an oxidative interrupted click reaction, using air as the sole terminal oxidant. The current protocol provides a novel method for the one-step construction of fully substituted triazoles in good yields under mild conditions, in which arylboronic acids are employed as aromatic sources to interrupt the cuprate–triazole intermediate for the first time.

Graphical abstract: A facile synthesis of diverse 5-arylated triazoles via a Cu-catalyzed oxidative interrupted click reaction with arylboronic acids in air

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Article information


Submitted
13 Jun 2018
Accepted
03 Jul 2018
First published
04 Jul 2018

Org. Chem. Front., 2018,5, 2463-2467
Article type
Research Article

A facile synthesis of diverse 5-arylated triazoles via a Cu-catalyzed oxidative interrupted click reaction with arylboronic acids in air

X. Yu, J. Xu, Y. Zhou and Q. Song, Org. Chem. Front., 2018, 5, 2463
DOI: 10.1039/C8QO00590G

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