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A Facile Synthesis of Diverse 5-Arylated Triazoles via Cu-Catalyzed Nucleophilic Interrupted Click Reaction with Arylboronic Acids under Air Conditions

Abstract

We herein disclose a Cu-catalyzed synthesis of 5-arylsubstituted 1,2,3-triazoles via nucleophilic interrupted click reaction, using air as sole terminal oxidant. The current protocol provides a novel method for one-step construction of fully substituted triazoles in good yields under mild conditions, in which arylboronic acids are employed as nucleophilic aromatic sources to interrupt the cuprate-triazole intermediate for the first time.

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Publication details

The article was received on 13 Jun 2018, accepted on 03 Jul 2018 and first published on 04 Jul 2018


Article type: Research Article
DOI: 10.1039/C8QO00590G
Citation: Org. Chem. Front., 2018, Accepted Manuscript
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    A Facile Synthesis of Diverse 5-Arylated Triazoles via Cu-Catalyzed Nucleophilic Interrupted Click Reaction with Arylboronic Acids under Air Conditions

    X. Yu, J. Xu, Y. Zhou and Q. Song, Org. Chem. Front., 2018, Accepted Manuscript , DOI: 10.1039/C8QO00590G

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