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1,4-Refunctionalization of β-diketones to γ-keto nitriles via C–C single bond cleavage

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Abstract

The 1,4-refunctionalization of β-diketones to γ-keto nitriles was realized via an Fe-catalyzed cascade radical process. The C–C single bond cleavage occurred at the less sterically hindered alkyl ketone side or at the side of β-diarylketones with electron-withdrawing groups. The reaction mechanism was proposed with respect to ESI-MS analysis results.

Graphical abstract: 1,4-Refunctionalization of β-diketones to γ-keto nitriles via C–C single bond cleavage

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Publication details

The article was received on 06 Jun 2018, accepted on 11 Jul 2018 and first published on 12 Jul 2018


Article type: Research Article
DOI: 10.1039/C8QO00556G
Citation: Org. Chem. Front., 2018, Advance Article
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    1,4-Refunctionalization of β-diketones to γ-keto nitriles via C–C single bond cleavage

    Q. Wu, Y. Li, C. Wang, J. Zhang, M. Huang, J. K. Kim and Y. Wu, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C8QO00556G

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