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Issue 11, 2018
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Pd-Catalyzed one-pot dehydroxylative coupling of phenols with K4[Fe(CN)6] mediated by SO2F2: a practical method for the direct conversion of phenols to aryl nitriles

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Abstract

We have developed a Pd-catalyzed direct dehydroxylative cyanation of phenols by employing an inexpensive food additive, potassium ferrocyanide (K4[Fe(CN)6]), as the cyanating reagent instead of highly toxic cyanide salts. This protocol provides a strategically distinct approach for the preparation of aryl nitriles in a safe, mild, convenient and practical manner.

Graphical abstract: Pd-Catalyzed one-pot dehydroxylative coupling of phenols with K4[Fe(CN)6] mediated by SO2F2: a practical method for the direct conversion of phenols to aryl nitriles

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Article information


Submitted
19 Mar 2018
Accepted
24 Apr 2018
First published
24 Apr 2018

Org. Chem. Front., 2018,5, 1835-1839
Article type
Research Article

Pd-Catalyzed one-pot dehydroxylative coupling of phenols with K4[Fe(CN)6] mediated by SO2F2: a practical method for the direct conversion of phenols to aryl nitriles

C. Zhao, W. Fang, K. P. Rakesh and H. Qin, Org. Chem. Front., 2018, 5, 1835
DOI: 10.1039/C8QO00295A

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