Issue 10, 2016

Aliphatic C–H azidation through a peroxydisulfate induced radical pathway

Abstract

A persulfate induced radical process to transform aliphatic tertiary C–H bonds into organic azides under transition-metal-free conditions has been developed. This method exhibits good chemo- and regioselectivity. A wide range of functional groups, including esters, halogens, azides, and dipeptides, are all tolerated well through the radical pathway, thus expanding the potential application of this method.

Graphical abstract: Aliphatic C–H azidation through a peroxydisulfate induced radical pathway

Supplementary files

Article information

Article type
Research Article
Submitted
30 May 2016
Accepted
10 Aug 2016
First published
18 Aug 2016

Org. Chem. Front., 2016,3, 1326-1330

Aliphatic C–H azidation through a peroxydisulfate induced radical pathway

X. Li and Z. Shi, Org. Chem. Front., 2016, 3, 1326 DOI: 10.1039/C6QO00237D

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