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Ultrasensitive detection of seventeen chemicals simultaneously based on paper sensor

Abstract

We developed an ultrasensitive gold nanoparticle-based multicomponent lateral-flow strip assay for simultaneous detection of seventeen hormone drugs from three classes: nandrolone (NR) and its analogues, dexamethasone (DEX) and its analogues, and hexestrol (HES) and its analogues. The antibodies and coating antigens were selected for the assay and the multi-immunochromatographic strip (multi-ICS) exhibited a very low limit of detection (LOD). The quantitative results were obtained using a strip scan reader, giving LOD values of 0.06–4.85 ng/mL for NR and its analogues, 0.005–2.85 ng/mL for DEX and its analogues, and 0.03–2.14 ng/mL for HES and its analogues. The recovery rates from milk samples were 85.8%–93.3% for NR, 78.8%–87.5% for DEX, and 89.4%–99.4% for HES. This multi-ICS assay therefore provides a useful tool for on-site detection and rapid initial screening of hormone drugs in biological samples.

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Publication details

The article was received on 08 Jul 2018, accepted on 28 Jul 2018 and first published on 30 Jul 2018


Article type: Research Article
DOI: 10.1039/C8QM00336J
Citation: Mater. Chem. Front., 2018, Accepted Manuscript
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    Ultrasensitive detection of seventeen chemicals simultaneously based on paper sensor

    Z. wang, L. sun, L. Liu, H. Kang, L. Xu and C. Xu, Mater. Chem. Front., 2018, Accepted Manuscript , DOI: 10.1039/C8QM00336J

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