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Issue 11, 2018
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Gamma radiation-responsive side-chain tellurium-containing polymer for cancer therapy

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Abstract

The combination of chemotherapy and radiotherapy could not only enhance cancer treatment efficacy, but also shorten the period of the overall treatment and relieve the anxiety of the patients during the remedy. Herein, we present a novel strategy for coordinating the chemotherapy drug CDDP with a tellurium-containing polymer, which restrained the tumour cytotoxicity of these two portions. After a low dose of γ radiation, CDDP departed from the coordination complexes, and the tumour cytotoxicity of both was restored. In contrast to conventional chemotherapy, this radiation responsive system possesses specific anticancer effects and less toxicity in the non-radiation therapy. In addition, with regard to the premise of therapeutic efficiency, this system effectively lowered the radiated dosage.

Graphical abstract: Gamma radiation-responsive side-chain tellurium-containing polymer for cancer therapy

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Supplementary files

Publication details

The article was received on 02 Jul 2018, accepted on 13 Sep 2018 and first published on 14 Sep 2018


Article type: Research Article
DOI: 10.1039/C8QM00321A
Citation: Mater. Chem. Front., 2018,2, 2109-2115
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    Gamma radiation-responsive side-chain tellurium-containing polymer for cancer therapy

    F. Fan, S. Gao, S. Ji, Y. Fu, P. Zhang and H. Xu, Mater. Chem. Front., 2018, 2, 2109
    DOI: 10.1039/C8QM00321A

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