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Luminescent supramolecular polymer nanoparticles for ratiometric hypoxia sensing, imaging and therapy

Abstract

Hydrogen-bonded supramolecular polymer nanoparticles (SPNPs) serving as ratiometric oxygen nanoprobe for hypoxia sensing and photodynamic therapy (PDT) treatment are designed. Herein, oxygen-sensitive phosphorescent Pt (II) porphyrin moiety and oxygen-insensitive fluorescent 9, 10-diphenylanthracene moiety are assembled through quadruple hydrogen bonding into SPNPs. An efficient energy transfer between the monomeric donor acceptor pairs in the SPNPs leads to enhanced phosphorescence with long lifetime. The resulting bright phosphorescence can realize hypoxia sensing in living cells and generate singlet oxygen efficiently in SPNPs to kill cancer cells. This is the first example of multi-functional supramolecular polymers based nanoprobe for ratiomeric hypoxia sensing, imaging and PDT treatment.

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Publication details

The article was received on 27 Jun 2018, accepted on 07 Aug 2018 and first published on 08 Aug 2018


Article type: Research Article
DOI: 10.1039/C8QM00309B
Citation: Mater. Chem. Front., 2018, Accepted Manuscript
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    Luminescent supramolecular polymer nanoparticles for ratiometric hypoxia sensing, imaging and therapy

    Y. Huang, Y. Tian, X. Liu, Z. Niu, Q. Yang, V. Ramamurthy, C. Tung, Y. Chen and L. Wu, Mater. Chem. Front., 2018, Accepted Manuscript , DOI: 10.1039/C8QM00309B

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