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(2-(4-bromophenyl)ethene-1,1,2-triyl)tribenzene with aggregation induced emission for ablation of HeLa cells

Abstract

It is of great importance for a photosensitizer to have good solubility and still remain high fluorescence simultaneously in aqueous solution. (2-(4-bromophenyl)ethene-1,1,2-triyl)tribenzene (denoted as ETTBr) with aggregation induced emission (AIE) was prepared. 1,2-distearoyl-sn-glycero-3-phospho-ethanolamine-N- [methoxy(polyethyleneglycol)-2000 (DSPE-PEG-2000) coated ETTBr nanoparticles (NPs) have strong ability to generate singlet oxygen by singlet oxygen sensor green (SOSG) as a probe and still remain high fluorescence in aqueous solution. In vitro cytotoxicity assay demonstrates that these NPs are able to kill Hela cells effectively and the half-maximal inhibitory concentration (IC50) is as low as 12 μg/mL. Furthermore, in vivo investigation suggests that ETTBr NPs are able to inhibit the growth of the tumor after irradiation without adverse effects to the normal organs, including heart, liver, spleen, lung and kidney, indicating the high low dark toxicity and excellent bio-compatibility of such NPs.

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Publication details

The article was received on 20 Jun 2018, accepted on 20 Jul 2018 and first published on 25 Jul 2018


Article type: Research Article
DOI: 10.1039/C8QM00304A
Citation: Mater. Chem. Front., 2018, Accepted Manuscript
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    (2-(4-bromophenyl)ethene-1,1,2-triyl)tribenzene with aggregation induced emission for ablation of HeLa cells

    J. Yang, X. Q. Gu, W. T. Su, X. Y. Hao, Y. J. Shi, L. Zhao, D. F. Zou, G. Yang, Q. Li and J. Zou (Joe), Mater. Chem. Front., 2018, Accepted Manuscript , DOI: 10.1039/C8QM00304A

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