Jump to main content
Jump to site search


Electrochemical detection of an antibiotic drug chloramphenicol based on a graphene oxide/hierarchical zinc oxide nanocomposite

Author affiliations

Abstract

A novel electrochemical sensor based on a graphene oxide (GO)/three-dimensional (3D) hierarchical zinc oxide (ZnO) nanocomposite was developed for the efficient determination of the antibiotic drug chloramphenicol (CAP). The hierarchical ZnO structure consisting of nanosheets was synthesized by a green aqueous solution procedure and then composited with GO through a simple sonochemical method. The synthesized ZnO and GO/ZnO nanomaterials were characterized by scanning electron microscopy (SEM), elemental mapping, X-ray diffraction (XRD), UV-Visible spectroscopy, Fourier transform infrared spectroscopy (FT-IR), and Raman spectroscopy. The electrochemical performance of the prepared GO/ZnO/glassy carbon electrode (GCE) was evaluated using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The GO/ZnO/GCE shows a low CAP detection limit of 0.01 μM, a high sensitivity of 7.27 μA μM−1 cm−2, and a linear response in the range of 0.2 to 7.2 μM. Moreover, it exhibits excellent stability, reproducibility and repeatability. Practicality of the sensor has further been demonstrated with honey, milk and eye drop samples.

Graphical abstract: Electrochemical detection of an antibiotic drug chloramphenicol based on a graphene oxide/hierarchical zinc oxide nanocomposite

Back to tab navigation

Publication details

The article was received on 19 Sep 2018, accepted on 02 Nov 2018 and first published on 02 Nov 2018


Article type: Research Article
DOI: 10.1039/C8QI01000E
Citation: Inorg. Chem. Front., 2018, Advance Article
  •   Request permissions

    Electrochemical detection of an antibiotic drug chloramphenicol based on a graphene oxide/hierarchical zinc oxide nanocomposite

    N. Sebastian, W. Yu and D. Balram, Inorg. Chem. Front., 2018, Advance Article , DOI: 10.1039/C8QI01000E

Search articles by author

Spotlight

Advertisements