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An AceDAN-Porphyrin(Zn) Dyad for Fluorescent Imaging and Photodynamic Therapy via Two-Photon Excited FRET

Abstract

The recent development of two-photon technique offers a unique opportunity to improve the depth of imaging and treatment in photodynamic therapy (PDT). Herein, we designed a FRET based AceDAN-Porphyrin(Zn) dyad for two-photon excited fluorescence imaging and PDT of cancer cells simultaneously, in which the AceDAN moiety was selected as the two-photon absorption donor, and the porphyrin(Zn) moiety served as the energy acceptor. Upon one-photon or two-photon excitation, the excited state energy of AceDAN donor was transferred to the porphyrin(Zn) acceptor with high efficiency (ηEET = 98%), where red fluorescence and singlet oxygen were generated. Dyad 1 exhibited high photocytotoxicity towards A549 cells (IC50 = 4.3 μM) with rapid cellular uptake while displayed low dark-cytotoxicity. Furthermore, by combining the advantages of two-photon excitation with porphyrin(Zn) photosensitizer, the AceDAN-Porphyrin(Zn) dyad has been successfully applied to A549 cells for imaging and photodynamic therapy under two-photon laser irradiation.

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Publication details

The article was received on 17 Jul 2018, accepted on 05 Oct 2018 and first published on 06 Oct 2018


Article type: Research Article
DOI: 10.1039/C8QI00705E
Citation: Inorg. Chem. Front., 2018, Accepted Manuscript
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    An AceDAN-Porphyrin(Zn) Dyad for Fluorescent Imaging and Photodynamic Therapy via Two-Photon Excited FRET

    M. Zhu, C. Su, P. Xing, Y. Zhou, L. Gong, J. Zhang, H. Du, Y. Bian and J. Jiang, Inorg. Chem. Front., 2018, Accepted Manuscript , DOI: 10.1039/C8QI00705E

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