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Polymer Conjugation of Biomolecules as Synthetic Post-translational Modification to Impact Stability and Activity

Abstract

For more than 40 years, protein-polymer conjugates have been widely used for many applications, industrially and biomedically. These bioconjugates have been shown to modulate the activity and stability of various proteins while introducing reusability and new activities that can be used for drug delivery, improve pharmacokinetic ability, and stimuli-responsiveness. Techniques such as RDRP, ROMP and “click” have routinely been utilized for development of well-defined bioconjugate and polymeric materials. Synthesis of bioconjugate materials often take advantage of natural amino acids present within protein and peptide structures for a host of coupling chemistries. Polymer modification may elicit increased or decreased activity, activity retention under harsh conditions, prolonged activity in vivo and in vitro, and introduce stimuli responsiveness. Bioconjugation has resulted to modulated thermal stability, chemical stability, storage stability, half-life and reusability. In this review we aim to provide a brief state of the field, highlight a wide range of behaviors caused by polymer conjugation, and provide areas of future work.

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Publication details

The article was received on 28 Sep 2018, accepted on 05 Dec 2018 and first published on 07 Dec 2018


Article type: Review Article
DOI: 10.1039/C8PY01399C
Citation: Polym. Chem., 2018, Accepted Manuscript
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    Polymer Conjugation of Biomolecules as Synthetic Post-translational Modification to Impact Stability and Activity

    T. A. Wright, R. C. Page and D. Konkolewicz, Polym. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8PY01399C

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