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Issue 44, 2018
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Polymerization of long chain alkyl glycidyl ethers: a platform for micellar gels with tailor-made melting points

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Abstract

Controlled polymerization of long-chain alkyl glycidyl ethers (AlkGE) under anionic ring opening polymerization conditions is enabled by the addition of a crown ether (18-crown-6, K+). Homopolymers with molecular weights in the range of 4000 to 9000 g mol−1 and side chain melting temperatures of 14 °C (C12-AlkGE) and 43 °C (C16-AlkGE), respectively were synthesized. Furthermore, a series of amphiphilic ABA polyether triblock copolymers with polyethylene glycol (PEG) as the hydrophilic central block (Mn = 6k, 10k, and 20k g mol−1) with total molecular weights in the range of 7000 to 28 000 g mol−1 and narrow dispersity (1.12 to 1.34) were prepared. Separate melting endotherms of the triblock copolymers were observed for these double-crystalline materials. Due to self-assembly of the hydrophobic alkyl chains, the addition of water or water/ethanol mixtures to the triblock copolymers leads to the formation of micellar, one-component hydrogels. By varying the repeating units of the hydrophobic PAlkGE blocks, a tunable hydrophobic effect can be achieved. Variation of the alkyl chain length enables tailoring of the melting temperatures of the PAlkGE-blocks both in bulk and hydrogels. Thermal and rheological investigation of ethanol/water gels revealed temperature-dependent mechanical behavior, indicating a transition from crystalline to flexible micellar hydrophobic domains in the range of 12 °C to 31 °C. The amphiphilic polyether triblock copolymers enable the preparation of guest-loaded thermo-responsive gels and hydrogels and bear promise for pharmaceutical applications, e.g. as drug release systems.

Graphical abstract: Polymerization of long chain alkyl glycidyl ethers: a platform for micellar gels with tailor-made melting points

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Supplementary files

Article information


Submitted
10 Sep 2018
Accepted
15 Oct 2018
First published
17 Oct 2018

Polym. Chem., 2018,9, 5327-5338
Article type
Paper

Polymerization of long chain alkyl glycidyl ethers: a platform for micellar gels with tailor-made melting points

P. Verkoyen, T. Johann, J. Blankenburg, C. Czysch and H. Frey, Polym. Chem., 2018, 9, 5327
DOI: 10.1039/C8PY01312H

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