Jump to main content
Jump to site search


Facile Preparation of Hyperbranched Glycopolymer via AB3* Inimer Promoted by a Hydroxy/Cerium (IV) Redox Process

Abstract

The facile preparation of hyperbranched glycopolymers was performed without protecting group chemistry, where the methyl-6-O-methacryloyl-α-D-glucoside (6-O-MMAGlc) monomer was adopted as AB3*-type inimer. The polymerization was initiated by hydroxy/cerium(IV) redox process, and could be named as the self-condensing vinyl copolymerization/redox (SCVP /Redox). The oxygen radical (C-O·), rather than carbon radical (·C-OH), was generated by the redox reaction of Ce(IV) with –OH groups on the pyranose in 6-O-MMAGlc, which was confirmed by the NMR data. The formation of branching point and linear chain growth were defined to give relative degree of branching (DBr). Linear increase of the DBr was observed as the concentration of Ce(IV) increased, implying the facile control of DBr. More interestingly, the inhibition activity of the hyperbranched glycopolymers on amyloid fibrillation of hen egg-white lysozyme (HEWL) exhibited a more positive response than that of linear analogue. This substantial study would provide more room to enrich the family of glycopolymers and extend their potential application in biomedicine and biomaterials.

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 Aug 2018, accepted on 13 Sep 2018 and first published on 15 Sep 2018


Article type: Paper
DOI: 10.1039/C8PY01134F
Citation: Polym. Chem., 2018, Accepted Manuscript
  •   Request permissions

    Facile Preparation of Hyperbranched Glycopolymer via AB3* Inimer Promoted by a Hydroxy/Cerium (IV) Redox Process

    F. Liu, Y. Wu, L. Bai, X. Peng, H. Zhang, Y. Zhang, P. An, S. Wang, G. Ma and X. Ba, Polym. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8PY01134F

Search articles by author

Spotlight

Advertisements